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DrSeyed Mohammad Taghdisi Heidarian
Assistant Professor of Pharmaceutical Biotechnology
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Address: Targeted Drug Delivery Research Center Department of Pharmaceutical Biotechnology School of pharmacy, Mashhad University of Medical Sciences Mashhad, IRAN Tel: (051) 38813255 Fax(051) 38813251
taghdisihm@mums.ac.ir This email address is being protected from spambots. You need JavaScript enabled to view it. Updated at: |
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und Educational Background |
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Pharm D supervisor: Dr. Hosseinimehr, Dr. Emami Research Field: Bioorganic and Medicinal Chemistry Pharm D thesis: Synthesis of 5,7-Dihydroxychromone-2-carboxylic acid
PhD supervisor: Dr Abnous and Dr. Behravan Research Field: Targeted delivery, Aptamer and Biotechnology PhD thesis: Generation of aptamers for MCF-7 cells and using them for targeted delivery of siRNA to breast cancers
Supervisor: Prof. Mayer
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Research Interests |
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Aptamers, Aptasensors (electrochemical, colorimetric and fluorescent aptasensors), Cell-SELEX, SELEX, Targeted drug delivery |
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Publications |
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Raeisossadati MJ, Danesh NM, Borna F, Gholamzad M, Ramezani M, Abnous K, Taghdisi SM. Lateral flow based immunobiosensors for detection of food contaminants. Biosensors and Bioelectronics. 2016. (IF=7.47) 2. Yazdian-Robati R, Ramezani M, Jalalian SH, Abnous K, Taghdisi SM. Targeted Delivery of Epirubicin to Cancer Cells by Polyvalent Aptamer System in vitro and in vivo. Pharmaceutical Research. 2016:1-9. (IF=3.26) 3. Nameghi MA, Danesh NM, Ramezani M, Hassani FV, Abnous K, Taghdisi SM. A fluorescent aptasensor based on a DNA pyramid nanostructure for ultrasensitive detection of ochratoxin A. Anal Bioanal Chem. 2016. Epub 2016/06/18. (IF=3.12) 4. Taghdisi SM, Danesh NM, Ramezani M, Abnous K. A novel M-shape electrochemical aptasensor for ultrasensitive detection of tetracyclines. Biosensors and Bioelectronics. 2016;85:509-14. (IF=7.47) 5. Abnous K, Danesh NM, Ramezani M, Taghdisi SM, Emrani AS. A novel electrochemical aptasensor based on H-shape structure of aptamer-complimentary strands conjugate for ultrasensitive detection of cocaine. Sensors and Actuators, B: Chemical. 2016;224:351-5. (IF=4.75) 6. Abnous K, Danesh NM, Sarreshtehdar Emrani A, Ramezani M, Taghdisi SM. A novel fluorescent aptasensor based on silica nanoparticles, PicoGreen and exonuclease III as a signal amplification method for ultrasensitive detection of myoglobin. Analytica Chimica Acta. 2016;917:71-8. (IF=4.71) 7. Danesh NM, Ramezani M, Emrani AS, Abnous K, Taghdisi SM. A novel electrochemical aptasensor based on arch-shape structure of aptamer-complimentary strand conjugate and exonuclease I for sensitive detection of streptomycin. Biosensors and Bioelectronics. 2016;75:123-8. (IF=7.47) 8. Emrani AS, Danesh NM, Lavaee P, Ramezani M, Abnous K, Taghdisi SM. Colorimetric and fluorescence quenching aptasensors for detection of streptomycin in blood serum and milk based on double-stranded DNA and gold nanoparticles. Food Chemistry. 2016;190:115-21. (IF=4) 9. Emrani AS, Danesh NM, Ramezani M, Taghdisi SM, Abnous K. A novel fluorescent aptasensor based on hairpin structure of complementary strand of aptamer and nanoparticles as a signal amplification approach for ultrasensitive detection of cocaine. Biosensors and Bioelectronics. 2016;79:288-93. (IF=7.47) 10. Hashemzaei M, Karami SP, Delaramifar A, Sheidary A, Tabrizian K, Rezaee R, Taghdisi SM. Anticancer effects of co-administration of daunorubicin and resveratrol in MOLT-4, U266 B1 and Raji cell lines. Farmacia. 2016;64(1):36-42. (IF=1.16) 11. Khansarizadeh M, Mokhtarzadeh A, Rashedinia M, Taghdisi SM, Lari P, Abnous KH, et al. Identification of possible cytotoxicity mechanism of polyethylenimine by proteomics analysis. Human and Experimental Toxicology. 2016;35(4):377-87. (IF=1.6) 12. Moghadam M, Sankian M, Abnous K, Varasteh A, Taghdisi SM, Mahmoudi M, et al. Cell-SELEX-based selection and characterization of a G-quadruplex DNA aptamer against mouse dendritic cells. International Immunopharmacology. 2016;36:324-32. (IF=2.55) 13. Ramezani M, Danesh NM, Lavaee P, Abnous K, Taghdisi SM. A selective and sensitive fluorescent aptasensor for detection of kanamycin based on catalytic recycling activity of exonuclease III and gold nanoparticles. Sensors and Actuators, B: Chemical. 2016;222:1-7. (IF=4.75) 14. Robati RY, Arab A, Ramezani M, Langroodi FA, Abnous K, Taghdisi SM. Aptasensors for quantitative detection of kanamycin. Biosensors and Bioelectronics. 2016;82:162-72. (IF=7.47) 15. Soheili V, Taghdisi SM, Hassanzadeh Khayyat M, Fazly Bazzaz BBS, Ramezani M, Abnous K. Colorimetric and ratiometric aggregation assay for streptomycin using gold nanoparticles and a new and highly specific aptamer. Microchimica Acta. 2016;183(5):1687-97. (IF=4.83) 16. Taghdisi SM, Danesh NM, Beheshti HR, Ramezani M, Abnous K. A novel fluorescent aptasensor based on gold and silica nanoparticles for the ultrasensitive detection of ochratoxin A. Nanoscale. 2016;8(6):3439-46. (IF=7.76) 17. Taghdisi SM, Danesh NM, Lavaee P, Emrani AS, Hassanabad KY, Ramezani M, et al. Double targeting, controlled release and reversible delivery of daunorubicin to cancer cells by polyvalent aptamers-modified gold nanoparticles. Materials Science and Engineering C. 2016;61:753-61. (IF=3.42) 18. Taghdisi SM, Danesh NM, Lavaee P, Ramezani M, Abnous K. An electrochemical aptasensor based on gold nanoparticles, thionine and hairpin structure of complementary strand of aptamer for ultrasensitive detection of lead. Sensors and Actuators, B: Chemical. 2016;234:462-9. (IF=4.75) 19. Taghdisi SM, Danesh NM, Nameghi MA, Ramezani M, Abnous K. A label-free fluorescent aptasensor for selective and sensitive detection of streptomycin in milk and blood serum. Food Chemistry. 2016;203:145-9. (IF=4) 20. Taghdisi SM, Danesh NM, Ramezani M, Abnous K. Targeted delivery of vincristine to T-cell acute lymphoblastic leukemia cells using an aptamer-modified albumin conjugate. RSC Advances. 2016;6(52):46366-71. (IF=3.28) 21. Taghdisi SM, Danesh NM, Ramezani M, Emrani AS, Abnous K. A novel electrochemical aptasensor based on Y-shape structure of dual-aptamer-complementary strand conjugate for ultrasensitive detection of myoglobin. Biosensors and Bioelectronics. 2016;80:532-7. (IF=7.47) 22. Taghdisi SM, Danesh NM, Ramezani M, Lavaee P, Jalalian SH, Robati RY, et al. Double targeting and aptamer-assisted controlled release delivery of epirubicin to cancer cells by aptamers-based dendrimer in vitro and in vivo. European Journal of Pharmaceutics and Biopharmaceutics. 2016;102:152-8. (IF=3.97) 23. Abnous K, Danesh NM, Ramezani M, Emrani AS, Taghdisi SM. A novel colorimetric sandwich aptasensor based on an indirect competitive enzyme-free method for ultrasensitive detection of chloramphenicol. Biosensors and Bioelectronics. 2016;78:80-6. (IF=7.47) 24. Taghdisi SM, Danesh NM, Lavaee P, Sarreshtehdar Emrani A, Ramezani M, Abnous K. Aptamer Biosensor for Selective and Rapid Determination of Insulin. Analytical Letters. 2015;48(4):672-81. (IF=1.08) 25. Taghdisi SM, Danesh NM, Lavaee P, Ramezani M, Abnous K. An aptasensor for selective, sensitive and fast detection of lead(II) based on polyethyleneimine and gold nanoparticles. Environmental toxicology and pharmacology. 2015;39(3):1206-11. (IF=2.18) 26. Taghdisi SM, Danesh NM, Lavaee P, Emrani AS, Ramezani M, Abnous K. A novel colorimetric triple-helix molecular switch aptasensor based on peroxidase-like activity of gold nanoparticles for ultrasensitive detection of lead(II). RSC Advances. 2015;5(54):43508-14. (IF=3.28) 27. Taghdisi SM, Danesh NM, Emrani AS, Ramezani M, Abnous K. A novel electrochemical aptasensor based on single-walled carbon nanotubes, gold electrode and complimentary strand of aptamer for ultrasensitive detection of cocaine. Biosensors & bioelectronics. 2015;73:245-50. (IF=7.47) 28. Sarreshtehdar Emrani A, Danesh NM, Lavaee P, Jalalian SH, Ramezani M, Abnous K, Taghdisi SM. Sensitive and selective detection of digoxin based on fluorescence quenching and colorimetric aptasensors. Analytical Methods. 2015;7(8):3419-24. (IF=1.91) 29. Ramezani M, Mohammad Danesh N, Lavaee P, Abnous K, Taghdisi SM. A novel colorimetric triple-helix molecular switch aptasensor for ultrasensitive detection of tetracycline. Biosensors and Bioelectronics. 2015;70:181-7. (IF=7.47) 30. Moosavian SA, Jaafari MR, Taghdisi SM, Mosaffa F, Badiee A, Abnous K. Development of RNA aptamers as molecular probes for HER2+ breast cancer study using cell-SELEX. Iranian Journal of Basic Medical Sciences. 2015;18(6):576-86. (IF=1.2) 31. Khabbaz LS, Hassanzadeh-Khayyat M, Zaree P, Ramezani M, Abnous K, Taghdisi SM. Detection of kanamycin by using an aptamer-based biosensor using silica nanoparticles. Analytical Methods. 2015;7(20):8611-6. (IF=1.91) 32. Jalalian SH, Taghdisi SM, Danesh NM, Bakhtiari H, Lavaee P, Ramezani M, et al. Sensitive and fast detection of tetracycline using an aptasensor. Analytical Methods. 2015;7(6):2523-8. (IF=1.91) 33. Emrani AS, Taghdisi SM, Danesh NM, Jalalian SH, Ramezani M, Abnous K. A novel fluorescent aptasensor for selective and sensitive detection of digoxin based on silica nanoparticles. Analytical Methods. 2015;7(9):3814-8. (IF=1.91) 34. Danesh NM, Lavaee P, Ramezani M, Abnous K, Taghdisi SM. Targeted and controlled release delivery of daunorubicin to T-cell acute lymphoblastic leukemia by aptamer-modified gold nanoparticles. Int J Pharm. 2015;489:311-7. (IF=3.99) 35. Taghdisi SM, Schöler KMU, Mayer G. Aptamers and use of the aptamers in the diagnosis and treatment of cancer. European Patent. 03.12.2014. 13169493.7. 36. Taghdisi SM, Emrani SS, Tabrizian K, Ramezani M, Abnous K, Emrani AS. Ultrasensitive detection of lead (II) based on fluorescent aptamer-functionalized carbon nanotubes. Environmental toxicology and pharmacology. 2014;37(3):1236-42. (IF=2.18) 37. Taghdisi SM, Danesh NM, Sarreshtehdar Emrani A, Tabrizian K, Zandkarimi M, Ramezani M, et al. Targeted delivery of Epirubicin to cancer cells by PEGylated A10 aptamer. Journal of drug targeting. 2013;21(8):739-44. (IF=2.82) 38. Jalalian SH, Taghdisi SM, Shahidi Hamedani N, Kalat SA, Lavaee P, Zandkarimi M, et al. Epirubicin loaded super paramagnetic iron oxide nanoparticle-aptamer bioconjugate for combined colon cancer therapy and imaging in vivo. European journal of pharmaceutical sciences. 2013;50(2):191-7. (IF=3.77) 39. Taghdisi SM, Lavaee P, Ramezani M, Abnous K. Reversible targeting and controlled release delivery of daunorubicin to cancer cells by aptamer-wrapped carbon nanotubes. European journal of pharmaceutics and biopharmaceutics. 2011;77(2):200-6. (IF=3.97) 40. Entezari Heravi R, Hadizadeh F, Sankian M, Tavakol Afshari J, Taghdisi SM, Jafarian H, et al. Novel selective Cox-2 inhibitors induce apoptosis in Caco-2 colorectal carcinoma cell line. European journal of pharmaceutical sciences. 2011;44(4):479-86. (IF=3.77) 41. Taghdisi SM, Abnous K, Mosaffa F, Behravan J. Targeted delivery of daunorubicin to T-cell acute lymphoblastic leukemia by aptamer. Journal of drug targeting. 2010;18(4):277-81. (IF=2.82) 42. Hosseinimehr SJ, Emami S, Taghdisi SM, Akhlaghpoor S. 5,7-Dihydroxychromone-2-carboxylic acid and it's transition-metal (Mn and Zn) chelates as non-thiol radioprotective agents. European journal of medicinal chemistry. 2008;43(3):557-61. (IF=3.9) 43. Emami S, Hosseinimehr SJ, Taghdisi SM, Akhlaghpoor S. Kojic acid and its manganese and zinc complexes as potential radioprotective agents. Bioorganic & medicinal chemistry letters. 2007;17(1):45-8. (IF=2.48)
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Presentations |
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Oral Presentation
1) Taghdisi SM., et al. Targeted delivery of daunorubicin to T-cell acute lymphoblastic leukemia by aptamer .The First Research Festival of Mashhad University of medical sciences, 2010.
2) Taghdisi SM., et al. Reversible Targeting and controlled release delivery of daunorubicin to cancer cells by aptamer-wrapped carbon nanotubes. The Second Research Festival of Mashhad University of medical sciences, 2011.
3) Taghdisi SM., et al. Novel broad-spectrum aptamers for tumour cell deprivation .The Third Research Festival of Mashhad University of medical sciences, 2011.
Poster presentation
1) Taghdisisi SM., et al. Recent advances in graphene and related material, Singapore 2010.
2) Taghdisi SM., et al. Specialized festival of position of nano drugs, nano biotechnology, nano biosensors and nano materials in medical sciences, Mashhad, 2009.
3) Taghdisi SM., et al. The 13th Iranian Pharmacy Students seminar, Tabriz, 2007.
4) Taghdisi SM., et al. The 10th Iranian Pharmacy Students seminar, Mashhad, 2004.
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Honors & Awards |
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1) Top Ph.D student in the board exam of Mashhad University of Medical Sciences (Pharmaceutical Biotechnology) 2009.
2) The best lecturer in the Second Research Festival of Mashhad University of Medical sciences, 2011.
3) The best lecturer in the Third Research Festival of Mashhad University of Medical Sciences, 2011.
4) Top researcher in the Research Festival of Mashhad University of Medical Sciences, 2015.
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Members hip Membership |
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Administrative Responsibilities |
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Other Skills |
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