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Dr. Sadeghi

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Dr Fatemeh Sadeghi

 

 

 

Professor of Pharmaceutics

 

        [at]mums.ac.ir
[at]yahoo.com

  

Address:   School of Pharmacy, Mashhad University of Medical Sciences, P.O Box: 91775-1365, Mashhad, Iran

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                                                       und Educational Background 

1992-1996:      Doctor of Philosophy degree (PhD) in Pharmaceutical Technology from School of Pharmacy, Liverpool John Moores University, Liverpool, UK

1985-1990:       Doctoral course of pharmacy (Pharm. D.), School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

 

                                                                   Research Interests

Formulation of sustained and controlled release matrices and reservoirs for oral delivery

Development of techniques to increase the solubility and dissolution rate of poorly water soluble drugs

Film coating

Solid dispersion systems

Microencapsulation of solid and liquid drugs

Pelletization using extrusion-spheronization technique

Formulation of colon delivery systems

Formulation of solid dosage forms

Polymersome drug delivery system

                                                                       Publications
  1. Sharifi, F., Hadizadeh, F., Sdaeghi, F. Mosavian, H., Zarei, C. Process Optimization, Physical Properties, and Environmental Stability of an α-Tocopherol Nanocapsule Preparation Using Complex Coacervation Method and Full Factorial Design.  Chem. Eng. Commun. 2016 203 (1), pp. 64-74.

 

  1. Alibolandi, M., Alabdollah, F.,Sadeghi, F. Ramezani, M.,Hadizadeh, F. Dextran-b-poly (lactide-co-glycolide) polymersome for oral delivery of insulin: In vitro and in vivo evaluation. J Control Release. 2016, 227; 58-70.

 

 

  1. Alibolandi, M., Abnous, K., Sadeghi, F. Ramezani, M., Hadizadeh, F. Folate receptor-targeted multimodal polymersomes for delivery of quantum dots and doxorubicin to breast adenocarcinoma: In vitro and in vivo evaluation. Int. J Pharm. 2016, 500; 162-178.

 

  1.   Afrasiabi Garekani, H., Faghihnia Torshizi, M., Sadeghi, F., Surelease as granulating liquid in preparation of sustained release matrices of ethylcellulose and theophylline. Drug Dev. Ind. Pharm. (2015) 41: 1655-1660.

 

  1.  Alibolandi, M. Ramezani, M. Abnous, K,  Sadeghi, F., Hadizadeh, F. Comparative evaluation of polymersome versus micelle structures as vehicles for the controlled release of drugs. J Nanopart Res (2015) 17:76 1-16.

 

  1. Alibolandi, M., Sadeghi, F., Sazmand, S.H., Shahrokh, SM, Seifi,M., Hadizadeh, F. Synthesis and self-assembly of biodegradable polyethylene glycol-poly (lactic acid) diblock copolymers as polymersomes for preparation of sustained release system of doxorubicin. Int. J. Pharm. Inv. (2015) 5:134- 141.

 

  1.  Afrasiabi Garekani, H, Sedighi, S, Sadeghi, F.  Surelease or organic solution of ethylcellulose in preparation of sustained release theophylline micromatrices or matrices using spray drying technique.  Pharm Dev Technol, 2015; 20: 204–210.

 

  1. Alibolandi, M., Ramezani, M., Sadeghi, F., Abnous, K, Hadizadeh, F. Epithelial cell adhesion molecule aptamer conjugated PEG–PLGA nanopolymersomes for targeted delivery of doxorubicin to human breast adenocarcinoma cell line in vitro. Int. J. Pharm. (2015) 479: 241-251.

 

  1. Alibolandi, M., Ramezani, M., Abnous,K., Sadeghi, F.,  Atyabi, F.,  Asouri, M., Ahmadi, A., Hadizadeh, F. In vitro and in vivo evaluation of therapy targeting epithelial-cell adhesion-molecule aptamers for non-small cell lung cancer. J control. Release. (2015) 209: 88-100

 

  1. Afrasiabi Garekani, H. Sedighi, S., Sadeghi, F.  Surelease or organic solution of ethylcellulose in preparation of sustained release theophylline micromatrices or matrices using spray drying technique.  Pharm Dev Technol, 20 (2015) 204–210.

 

  1. Homayouni, A., Sadeghi, F., Nokhodchi, A., Varshosaz, J., Afrasiabi Garekani.H. Preparation and Characterization of Celecoxib Dispersions in Soluplus®: Comparison of Spray Drying and Conventional Methods.   Iran J. Pharm.  Res (2015), 14 (1): 35-50.

 

  1. Homayouni, A., Sadeghi, F., Varshosaz, J., Afrasiabi Garekani, H., Nokhodchi, A.   Promising dissolution enhancement effect of soluplus on crystallized celecoxib obtained through antisolvent precipitation and high pressure homogenization techniques. Colloids and Surfaces B: Biointerfaces 122 (2014) 591– 600.

 

  1. Homayouni, A., Sadeghi, F., Varshosaz, J., Afrasiabi Garekani, H., Nokhodchi. A., Comparing various techniques to produce micro/nanoparticles for enhancing the dissolution of celecoxib containing PVP. Eur. J. Pharm. Biopharm. 88 (2014) 261-274.

 

  1. Homayouni, A., Sadeghi, F., Nokkhodchi, A., Varshosaz, J., Afrasiabi Garekani, H. Preparation and characterization of celecoxib solid dispersions; comparison of poloxamer-188 and PVP-K30 as carriers. Iran J. Basic. Med. Sci. 17 (2014) 322-331.

 

  1. Sadeghi, F., Torab, M., Khattab, M., Homayouni, A., Afrasiabi Garekani, H. Improvement of Physico-mechanical Properties of Partially Amorphous Acetaminophen Developed from Hydroalcoholic Solution Using Spray Drying Technique. Iran J. Basic. Med. Sci. 16 (2013) 1100- 1108.

 

  1. Afrasiabi Garekani, H., Fatemi Moghaddam, Z., Sadeghi, F. Organic solution versus aqueous dispersion of Eudragit RS inpreparation of sustained release microparticles of theophylline using spray drying.Colloids and Surfaces B: Biointerfaces 108 (2013) 374– 379.

 

  1. Afrasiabi Garekani, H., Nokhodchi, A., Amirpour Rayeni, M, Sadeghi, F. Preparation and characterization and release properties of Eudragit RS based ibuprofen pellets prepared by extrusion spheronization. Effect of binder type and concentration. Drug Dev. Ind. Pharm. 39 (2013) 1238–1246.

 

  1. Khodaverdi, E, Mirzazadeh Tekie, F.S, Sedaghat Amoli, S, Sadeghi, F. Comparison of Plasticizer Effect on Thermo-responsive Properties of Eudragit RS Films. AAPS PharmSciTech, (13) (2012) 1024-1030.

 

  1. Sadeghi, F., Shahabi, M., Afrasiabi Garekani, H. Comparison of physicomechanical properties of films prepared from organic solutions and aqueous dispersion of Eudragit RL. DARU 19(2) (2011) 100-106.

 

  1. Sadeghi, F., Hijazi, H., Afrasiabi Garekani, H. Production of ibuprofen pellets containing high amount of rate retarding Eudragit RL using PEG400 and investigation of their physicomechanical properties. Iran J. Basic Med. Sci. 14 (2011) 383-390.

 

  1. Sadeghi F, Sanadgol E., Afrasiabi Garekani H. The effect of granulating liquid and curing on the physicomechanical and release properties of pellets containing ibuprofen and Eudragit RL prepared by extrusion spheronization. Pharmaceutical Sciences,  Journal of Faculty of Pharmacy, Tabriz University of Medical Sciences 17 (2011) 103-118.

 

  1. Sadeghi F., Rakhshan M., Afrasiabi Garekani H. Preparation and evaluation of microcapsules containing propranolol hydrochloride using Eudragit polymers Pharmaceutical Sciences,  Journal of Faculty of Pharmacy, Tabriz University of Medical Sciences 17 ( 2011) 189 – 200.

 

  1.  Abbaspour, M.R., Sadeghi, F., Afrasiabi Garekani, H., Design and study of ibuprofen disintegrating sustained release tablets comprising coated pellets. Eur. J. Pharm. Biopharm. 68 (2008) 747-759.

 

  1. Sadeghi F., Kazemi Oskuee R., Nassirli H., Afrasiabi Garekani H. Effect of granulation process on physicomechanical properties of granules and compaction behaviour of hydroxypropyl methylcellulose with different degrees of methoxy/hydroxypropyl substitution. Pharmaceutical Sciences,  Journal of Faculty of Pharmacy, Tabriz University of Medical Sciences 15 (2009) 93- 102.

 

  1. Sadeghi, F., Eidi, M., Ansaripoor, N., Afrasiabi Garekani, H. Preparation and evaluation of microcapsules containing diclofenac sodium and Eudragit RS or RL as oral sustained release multiparticulate delivery system. Pharmaceutical Sciences. Journal of Faculty of Pharmacy, Tabriz University of Medical Sciences. 1 Spring (2008) 9-18.

 

  1. Sadeghi, F., Mosaffa, F., Afrasiabi Garekani, H. Effect of particle size, compaction force and presence of aerosil 200 on the properties of matrices prepared from physical mixture of propranolol hydrochloride and Eudragit RS or RL. Iran J. Basic Med. Sci. 10 (2007) 197-205.

 

  1. Abbaspour, M.R., Sadeghi, F., Afrasiabi Garekani, H., Thermal treating as a tool to produce plastic pellets based on Eudragit RS PO and RL PO aimed for tableting. Eur. J. Pharm. Biopharm. 67 (2007) 260-267.

 

  1. Akhagri, A., Sadeghi, F., Afrasiabi Garekani, H. Combination of time-dependent and pH-dependent polymthacrylates as a single coating formulation for colonic delivery of indomethacin pellets. Int.J. Pharm. 320 (2006) 137-142.

 

  1. Akhgari, A., Farahmand, F., Afrasiabi Garekani, H., Sadeghi, F., Vandamme, T.F., Permeability and swelling studies on free films containing inulin in combination with different polymethacrylates aimed for colonic drug delivery. Eur. J. Pharm. Sci. 28 (2006) 307-314.

 

  1. Sadeghi, F., Afrasiabi Garekani, H. Ghodsi, S.A. Evaluation of solid dispersion systems of acetaminophen and ethylcellulose, Eudragit RS or RL and the effect of solvent used in preparation of these systems on characteristics of matrices. Pharmaceutical Sciences. Journal of Faculty of Pharmacy, Tabriz University of Medical Sceinces. 1 Spring (2006) 47-54.

 

  1. Abbaspour, M.R., Sadeghi, F., Afrasiabi Garekani, H. Preparation and characterization of ibuprofen pellets based on Eudragit RS PO and RL PO or their combination. Int. J. Pharm., 303 (2005) 88-94.

 

  1. Akhgari A., Afrasiabi Garekani, H., Sadeghi, F. and  Azimaie, M. Statistical optimization of indomethacin pellets coated with pH-dependent methacrylic polymers for possible colonic drug delivery. Int. J. Pharm.,305 (2005) 22-30. 

 

  1. Sadeghi, F., Afrasiabi Garekani, H., Goli, F. Tableting of Eudragit RS and propranolol hydrochloride solid dispersion: Effect of particle size, compaction force and plasticizer addition on drug release. Drug Dev. Ind. Pharm. 30 (2004) 759-766.

 

  1. Abbaspour, M.R., Sadeghi, F., Afrasiabi Garekani, H. Effect of drug loading on physicomechanical and release properties of ibuprofen pellets prepared by extrusion-spheronization. Pharmaceutical Scienecs. Journal of Faculty of Pharmacy, Tabriz University of Medical Sceinces. 2 Autumn & Winter (2005) 55-64.

 

  1. Afrasiabi Garekani, H.,Sadeghi, F. Salary, M. 2004, Dissolution study of acetaminophen crystallized in the presence of polyvinylpyrrolidone., J. Drug Del. Sci. Tech. 14 (2004) 141-146.

 

  1. Sadeghi, F., Afrasiabi Garekani, H., Sadr, A. Influence of polymer viscosity and plasticizer addition on ethylcellulose matrix characteristics prepared from solid dispersion system. S.T.P. PHARMA SCIENCE. 13 (2003) 105-110.

 

  1. Sadeghi, F. Afrasiabi Garekani, H., Sadeghi, R. Comparison of ethylcellulose matrix characteristics prepared by solid dispersion technique or physical mixing. DARU, 11 (2003) 7-13.

 

  1. Sadeghi, F., Ford, J.L., Rajabi-Siahboomi, A.R. The influence of drug type on the release profiles from Surelease coated pellets. Int. J. Pharm. 254 (2003) 123-135.

 

  1. Garekani, H.A., Sadeghi, F., Firouzpoor, A. The influence of propylene glycol and moisture on the compaction properties of acetaminophen granules. S.T.P. PHARMA SCIENCE. 13 (2003) 335-339.

 

  1. Garekani, H.A., Sadeghi, F., Ghazi, A. Increasing the aqueous solubility of acetaminophen in presence of polyvinylpyrolidone and investigation of the mechanisms involved. Drug Dev. Ind. Pharm. 29 (2003) 173-179.

 

  1. Sadeghi, F., Afrasiabi Garekani, H., Hajiaghapoor, N., Evaluation of Eudragit RS and RL solid dispersion systems in preparation of diclofenac sodium sustained release matrices. Pharmaceutical Scienecs. Journal of Faculty of Pharmacy, Tabriz University of Medical Sciences. 2 Autumn & Winter (2003) 49-62

 

  1. Sadeghi, F., Ford, J.L., Rubinstein, M.H., Rajabi-Siahboomi, A.R. Study of drug release from pellets coated with  Surelease containing hydroxypropylmethylcellulose. Drug Dev. Ind. Pharm. 27 (2001) 416-427.

 

  1. Garekani, H.A., Sadeghi, F., Badiee, A., Mostafa, S.A., Rajabi-Siahboomi, A.R. Crystal habit modifications of ibuprofen and their physicomechanical characteristics. Drug Dev. Ind. Pharm. 27 (2001) 803-809.

 

  1. Sadeghi, F., Afrasiabi Garekani, H., Farzadnia, Z., Effect of polymer viscosity, polymer particle size and compaction force on diclofenac sodium release from ethylcellulose matrices.  Pharmaceutical Scienecs. Journal of Faculty of Pharmacy, Tabriz University of Medical Sciences. 2 Spring & Summer (2001) 45-56.

 

  1. Sadeghi, F., Ford, J.L., Rubinstein, M.H., Rajabi-Siahboomi, A.R. Comparative study of drug release from hydroxpropylmethylcellulose or Surelease coated pellets. Drug Dev. Ind. Pharm. 26 (2000) 651-660.

 

                                                                      Presentations

1- F. Sadeghi, Z. Fatemi Moghaddam, H. Afrasiabi Garekani. Preparation of Sustained Release Microparticles Containing Theophylline and Eudragit RS Using Spray Drying Technique: Comparison Between Organic Solution and Aqueous Dispersion of Polymer . 39th Annual Meeting & Exposition of the Controlled Release Society. July 2012, Qubec city, Canada.

2- H. Afrasiabi Garekani, M. khattab, F. Sadeghi.  Particle Engineering of Acetaminophen Via Spray Drying From Hydro-alcoholic Solutions: Improvement In Dissolution Rate . 39th Annual Meeting & Exposition of the Controlled Release Society. July 2012, Qubec city, Canada.

3- F. Sadeghi, Amirpoor Rayeni, M., Afrasiabi Garekani, H. The effect of HPMC type and concentration on physicomechanical and release properties of ibuprofen and Eudragit RS pellets prepared by extrusion spheronization. 3rd PharmSci fair, 2011. Prague, Czech.

4- F. Sadeghi, M. Amirpour Rayeni, H. Afrasiabi Garekani. Comparison of PVP K30, PVP K90 and HPMC 6cps as binder in preparation of Eudragit based ibuprofen matrix pellets prepared by extrusion-spheronization. (Oral presentation) 5th Iranian Controlled Release Conference, Mashhad, Iran, October 2011.

5- H. Afrasiabi Garekani, M. Torab, F. Sadeghi. Preparation of spray dried acetaminophen particles: Comparison of solution feed and suspension feed. 5th Iranian Controlled Release Conference, Mashhad, Iran, October 2011.

6-  A. Homayouni, H. Afrasiabi Garekani, M. Torab, F. Sadeghi. The influence of PVP on solid states and physic-mechanical properties of spray dried acetaminophen particles obtained from aqueous solutions. 5th Iranian Controlled Release Conference, Mashhad, Iran, October 2011.

7- F. Sadeghi, M.R. Abbaspour, H. Afrasiabi Garekani. The effect of coating level on mechanical and release properties of cured Eudragit based ibuprofen pellets. Pharmaceutical Science World Congress, Amsterdam, Netherland, April 2007.

8- H. Afrasiabi Garekani, A. Akhgari, F. Sadeghi. Comparison of permeability and swelling characteristics of free films containing pectin or inulin in combination with time dependent polymethacrylate aimed for colonic drug delivery. Pharmaceutical Science World Congress, Amsterdam, Netherland, April 2007.

9-  F.Sadeghi, M.R. Abbaspour, F., Tayarani, H. Afrasiabi Garekani. Mechanical and release behavior of ibuprofen pellets based on Eudragit RL plasticized with triethylcitrate. Biritish Pharmaceutical Conference, Manchester, UK, September 2006.

10-  H. Afrasiabi Garekani, A. Akhgari, F. Sadeghi. Combination of Inulin as a bacterially degradable polysaccharide and Eudragit RS to achieve colon delivery of indomethacin pellets. British Pharmaceutical Conference, Manchester, UK, September 2006.

11- F.Sadeghi, M.R. Abbaspour, H. Afrasiabi Garekani. Effect of thermal treating on release and physicomechanical properties of ibuprofen pellets based on Eudragit RS and RL. 2nd EUFEPS Conference on optimizing drug delivery and formulation: Evaluation of drug delivery systems issues and perspectives (Paris, France, November 2005)

12- H. Afrasiabi Garekani, A. Akhgari, F. Sadeghi, Combination of time-dependent and pH-dependent polymethacrylates as a single coating formulation for colonic delivery of indomethacin pellets. 2nd EUFEPS Conference on optimizing drug delivery and formulation: Evaluation of drug delivery systems issues and perspectives ( Paris, France, November 2005)

13- F. Sadeghi, H.A. Garekani, E.H. Moase, O. Meyer, T.M. Allen, Binding method for NGR-targeted liposomal doxorubicin using cells expressing the angiogenic marker CD13., Lipids, Liposomes, and Biomembranes Conference (Vancouver, Canada, July 2005).

14- Sadeghi, F.,  Abbaspour, M.R., Afrasiabi Grekani, H. Preparation and characterization of ibuprofen pellets based on Eudragit RS and RL or their combination. British Pharmaceutical Conference, Manchester, UK, September 2004.

15- Afrasiabi Garekani, H., Akhgari, A., Sadeghi, F. Indomethacin release from pellets coated with Eudragit S100 and Eudargit L100 combinations in media with different pH: an approach to colon delivery. British Pharmaceutical Conference, Manchester, UK, September 2004.

16- Kazemian, H., Hadizadeh, F., Sadeghi, F., Esmail-Nazari, Z. A zeolite based formulation of leukeran tablets: Synthesis, characterization and drug release evaluation. The 4th International Postgraduate Research Symposium on Pharmaceutics (IPORSIP). Istanbul, Turkey, September 2004.

17- Sadeghi, F., Afrasiabi Garekani, H., Goli, F. Solid dispersion of Eudragit RS and propranolol hydrochloride: Effect of particle size, compaction pressure and plasticizer addition. British Pharmaceutical conference, Harrogate, UK, September 2003.

18-  Afrasiabi Garekani, Sadeghi, F., Salary, M. Dissolution study of paracetamol crystalised in the presence of polyvinylpyrrolidon (PVP). British Pharmaceutical conference, Harrogate, UK, September 2003.

19-  Sadeghi, F. Sadr, A. Effect of plasticizer type and concentration on drug release from ethylcellulose matrices prepared by solid dispersion technique. British Pharmaceutical Conference, Manchester, UK, September 2002.

20- Sadeghi, F. Bakhshizadeh, M. Properties of granules and matrices of HPMC K4M prepared by wet granulation using different combinations of water and ethanol. “British Pharmaceutical Conference, Glascow, UK, September 2001.

21-  Sadeghi, F. Preparation of ethylcellulose matrices by solid dispersion. 19 th Pharmaceutical Technology Conference, Baveno- Stresa, Italy, April 2000. Published: Proceedings 19th Pharmaceutical Technology conference 2 (2000) 262-267.

22- Afrasiabi Garekani, H., Sadeghi, F., Badiee, A., Rajabi-Siahbomi, A.R. Crystal habit modifications of ibuprofen and their physico-mechanical characteristics.19 th Pharmaceutical Technology Conference, Baveno- Stresa, Italy, April 2000. Proceedings 19th Pharmaceutical Technology conference 2 (2000) 324-333.

23- Sadeghi, F., Ford, J.L., Rubinstein, M.H., Rajabi-Siahboomi, A.R. Drug release from HPMC E15 and Surelease coated microcapsules. 12 th International Symposium on Microencapsulation. London, 6-8 September 1999.

24- Sadeghi, F., Ford, J.L. Rubinstein, M.H., Rajabi- Siahboomi, A.R. "Effect of drug type on release behaviour from coated pellets "23rd International Symposium of Controlled Release of Bioactive Materials, Kyoto, Japan, July, 1996). Published: Proceedings International Symposium of Controlled Release of Bioactive Materials. 23 (1996)567-568.

25- Sadeghi. F., Ford, J.L., Rubinstein, M.H., Rajabi – Siahboomi, A.R., "Release Behaviour from coated pellets: Effect of drug type. 15 th Pharmaceutical Technology Conference, Oxford, U.K., March 1996. Published: Proceedings 15 th Pharmaceutical Technology conference 1 (1996) 289-306.

26- Sadeghi, F., Ford, J.L., Rubinstein, M.H., Rajabi-Siahboomi, A.R. "Metoclopramide hydrochloride release from coated pellets "14 th Pharmaceutical Technology Conference, Barcelona. Spain, April, 1995. Published: Proceedings 14th Pharmaceutical Technology Conference, 1 (1995) 424-437.

27- Sadeghi, F., Ford, J.L., Rubinstein, M.H., Rajabi-Siahboomi, A.R. "Effect of polymer type and coating load on drug release from coated pellets "British Pharmaceutical Conference (Warwick, U.K., September, 1995).

 

 

 

 

                                                                    Honors & Awards

Scholarship award for higher education by the Ministry of Health and Medical Education of Iran, 1992-1996.

First rank researcher at Mashhad University of Medical Sciences in 2005

Scholarship in learning and teaching at School of Pharmacy, Mashhad University of Medical Sciences in 2010

 

 

Members                                                  hip Membership

 

 

 

 

                                                           Administrative Responsibilities

Member of editorial board of Iranian Journal of Basic Medical Sciences

Member of editorial board of ISRN Pharmaceutics

 

Member of research committee of School of Pharmacy, Mashhad  University of Medical Sciences

Head of Pharmaceutical lab

 

 

Other Skills