|
Dr Abbas Akhgari
Assistant Professor of pharmaceutics
|
|
|
Address: Targeted Drug Delivery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Tel: +98 5138823255 Fax+98 5138823251
akhgaria@mums.ac.ir Updated at: june2016 |
|
|
und Educational Background |
|
|
Ph.D of pharmaceutics, School of Pharmacy, Mashhad University of Medical Science, Iran )2000-2006( - Scholarship in permeability of free films, School of pharmacy, Université Louis Pasteur, Strasbourg, France (2005) - Pharm.D from School of Pharmacy, Mashhad University of Medical Science, Iran )1993 -1999(
|
|
|
Research Interests |
|
|
Modified and Sustained Release formulations - Colonic delivery systems- Nanotechnology - Coating technology - pH-sensitive and controlled release polymers - Biodegradable systems - Drug permeability and diffusion - Experimental design – Powder technology |
|
|
Publications |
|
|
-Akhgari A., Afrasiabi Garekani H., Sadeghi F., Azimaie M. 2005. Statistical optimization of indomethacin pellets coated with pH-dependent methacrylic polymers for possible colonic drug delivery, Int. J. Pharm., 305, 22-30. -Akhgari A., Farahmand F., Afrasiabi Garekani H., Sadeghi F., Vandamme T.F. 2006. Permeability and swelling studies on free films containing inulin in combination with different polymethacrylates aimed for colonic drug delivery, Eur. J. Pharm. Sci., 28, 307-314. -Akhgari A., Sadeghi F., Afrasiabi Garekani H. 2006. Combination of time-dependent and pH-dependent polymethacrylates as a single coating formulation for colonic delivery of indomethacin pellets, Int. J. Pharm., 320, 137-142. - Akhgari A., Sadeghi F., Afrasiabi Garekani H. 2009. Combination of inulin and time dependent polymethacrylates as a coating system to achieve colonic delivery of indomethacin, DARU, 17(3), 199-208.
-Akhgari A., Farahmand F., Afrasiabi Garekani H., Sadeghi F., Vandamme T.F. 2010. The effect of pectin on swelling and permeability characteristics of free films containing Eudragit RL and/or RS as a coating formulation aimed for colonic drug delivery, DARU, 18(2), 91-96.
- Sharif Makhmal Zadeh B., Moshtaghi F., Rahim F., Akhgari A. 2010. Preparation and evaluation of sodium diclofenac loaded chitosan controlled release microparticles using factorial design, Int. J. Drug Dev. Res., 2(3), 468-475.
- Akhgari A., Abbaspour MR., Rezaee S., Kuchak A. 2011. Evaluation of the swelling, erosion and drug release from polysaccharide matrix tablets based on pectin and inulin, Jundishapur J. Nat. Pharm. Prod., 6(1), 51-58.
- Akhgari A., Abbaspour MR., Pirmoradi S. 2011. Preparation and evaluation of pellets using acacia and tragacanth by extrusion-spheronization, DARU, 19(6), 417-423.
- Abbaspour MR., Akhgari A., Beygi V. 2012. Effect of NSAIDs on thermomechanical properties and permeability of Eudragit RS free films, Der Pharmacia Letter, 4(1), 67-75.
- Akhgari A., Heshmati Z., Sharif Makhmalzadeh B. 2013. Indomethacin electrospun nanofibers for colonic drug delivery: preparation and characterization, Adv. Pharm. Bull., 3(1), 85-90.
- Akhgari A., Abbaspour MR., Moradkhanizadeh M. 2013. Combination of pectin and Eudragit RS and Eudragit RL in the matrix of pellets prepared by extrusion-spheronization for possible colonic delivery of 5-amino salicylic acid, Jundishapur J. Nat. Pharm. Prod., 8(2), 86-92.
- Akhgari A., Sadeghi H., Dabbagh MA. 2014. Modifying of flow and compressibility of corn starch using quasi-emulsion solvent diffusion method, Iran J. Basic Med. Sci., 17(8), 553-559.
- Jalali A., Moghimipour E., Akhgari A. 2014. Enhancing effect of bile salts on gastrointestinal absorption of insulin, Trop. J. Pharm. Res., 13(11), 1797-1802.
- Akhgari A., Saremi H., Khodayar MJ. 2015. Preparation and evaluation of vitamin A nanosuspension as a novel ocular drug delivery, Nanomed. J., 2(4), 283-290.
- Akhgari A. 2015. Role of Polysaccharides in Colon-Specific Drug Delivery, Jundishapur J. Nat. Pharm. Prod., 10(3), e30388.
- Akhgari A., Rotubati MH. 2016. Preparation and evaluation of electrospun nanofibers containing pectin and time-dependent polymers aimed for colonic drug delivery of celecoxib, Nanomed. J., 3(1), 43-48.
- Bavarsad N., Akhgari A., Seifmanesh S., Salimi A., Rezaie A. 2016. Statistical optimization of tretinoin-loaded penetration-enhancer vesicles (PEV) for topical delivery, DARU, 24(7), 1-12.
- Akhgari A., Tavakol A. 2016. Prediction of optimum combination of eudragit RS/eudragit RL/ethyl cellulose polymeric free films based on experimental design for using as a coating system for sustained release theophylline pellets, Adv. Pharm Bull., In Press.
- Akhgari A., Ghalambor Dezfuli A., Rezaei M., Kiarsi M., Abbaspour M. 2016. The design and evaluation of a fast-dissolving drug delivery system for loratadine using the electrospinning method, Jundishapur J. Nat. Pharm. Prod., In Press.
|
|
|
Presentations |
|
|
-Akhgari A., Afrasiabi Garekani H., Sadeghi F., Azimaie M. Statisical optimisation of indomethacin pellets coated with pH-dependent methacrylic polymers for possible colonic drug delivery, 9th Iranian Seminar of Pharmaceutical Science Conference, Tabriz, Iran, Aug. 2004.
-Afrasiabi Garekani H., Akhgari A., Sadeghi F., Azimaie M. Indomethacin release from pellets coated with Eudragit S100 and Eudragit L100 combinations in media with different pH: an approach to colon delivery, British Pharmaceutical Conference and Exhibition, Manchester, UK, Sep. 2004.
-Afrasiabi Garekani H., Akhgari A., Sadeghi F. Combination of time-dependent and pH-dependent polymethacrylates as a single coating formulation for colonic delivery of indomethacin pellets, 2nd EUFEPS Conference, Versailles, France, Nov. 2005.
-Afrasiabi Garekani H., Akhgari A., Sadeghi F. Drug targeting to colon: Effect of inulytic enzyme on the indomethacin release from pellets coated with Eudragit RL containing inulin, 15th World Congree of Pharmacology, Beijing, China, Jul. 2006.
-Vandamme T., Akhgari A., Farahmand F. Preparation and evaluation of free films containing inulin in combination with different polymethacrylates aimed for colonic drug delivery, 33rd Annual Meeting of the Controlled Release Society, Vienna, Austria, Jul. 2006.
-Akhgari A., Farahmand F., Afrasiabi Garekani H., Sadeghi F., Vandamme T.F. Permeability and swelling studies on free films containing pectin in combination with Eudragit RL and RS aimed for possible colonic drug delivery, 10th Iranian Seminar of Pharmaceutical Science Conference, Tehran, Iran, Aug. 2006.
-Afrasiabi Garekani H., Akhgari A., Sadeghi F. Combination of inulin as a bacterially degradable polysaccharide and Eudragit RS to achieve colon delivery of indomethacin pellets, British Pharmaceutical Conference and Exhibition, Manchester, UK, Sep. 2006.
- Afrasiabi Garekani H., Akhgari A., Sadeghi F. Comparison of permeability and swelling characteristics of free films containing pectin or inulin in combination with time dependent polymethaacrylate aimed for colonic drug delivery, Pharmaceutical Science World Congress, Amsterdam, Netherland, April 2007.
- Moghimipour E., Akhgari A., Ghassemian Z. Formulation of glucosamine effervescent granules, 11th Iranian Pharmaceutical Sciences Conference, 2008, Kerman, Iran.
- Akhgari A., Dabbagh M.A., Sadeghi H. Optimization of flow and compressibility characteristics of starch and lactose using quasi emulsion solvent diffusion method aimed for using in direct compression, 3rd BBBB International Conference on Pharmaceutical Sciences, 2009, Antalya, Turkey.
- Akhgari A., Dabbagh M.A., Sadeghi H. Modification of mannitol compressibility via quasi emulsion solvent diffusion, 7th World Meeting on Pharmaceutics, Biopharmcaeutics and Pharmaceutical Technology, 2010, Valletta, Malta.
- Abbaspour M., Akhgari A., Beygi V. Comparison effect of some NSAIDs on permeability and thermomechanical behavior of Eudragit RS free films, 12th Iranian Pharmaceutical Sciences Congress, 2010, Zanjan, Iran.
- Abbaspour MR., Akhgari A., Beygi V. Effect of indomethacin on thermomechanical properties and permeability of eudragit RS and eudragi S100 free films, 70th Intenational Congress of FIP, 2010, Lisbon, Portugal.
- Pirmoradi S., Abbaspour MR., Akhgari A. Preparation and evaluation of ibuprofen pellets by extrusion-spheronization using tragacanth and acacia as binder, 5th Iranian Controlled Release Conference, 2011, Mashhad, Iran.
- Akhgari A., Abbaspour MR., Moradkhanizadeh M. Preparation and evaluation of a colonic drug delivery system for 5-ASA pellets using combination of bacterially degradable polysaccharides and time-dependent polymethacrylates, 13th Iranian Pharmaceutical Sciences Congress, 2012, Isfahan, Iran. Published in Res. Pharm. Sci., 7(5) suppl. S244.
- Heshmati Z., Akhgari A., Sharif Makhmalzadeh B. Preparation and evaluation of electrospun indomethacin loaded Eudragit S100 and Eudragit RS100 nanofibers for colon-targeted drug delivery, 13th Iranian Pharmaceutical Sciences Congress, 2012, Isfahan, Iran. Published in Res. Pharm. Sci., 7(5) suppl. S245.
- Kalantari F., Akhgari A., Bavarsad N., Taghavi Moghaddam P., Nejati L., Imani S. The effects of pectin and chitosan on drug release from theophylline pellets made by extrusion-spheronization, 14th Iranian Pharmaceutical Sciences Congress, 2015, Tehran, Iran.
|
|
|
Honors & Awards |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Members hip Membership |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Administrative Responsibilities |
|
|
Reviewer of Journal of Pharmacy and Pharmacology- Drug Development and Industrial Pharmacy- Pharmaceutical Research
|
|
|
Other Skills |
|
|
Some works with fluidized bed coating, dissolution test, permeability of drug, water vapor transmission test, extruder and spheronizer, tableting machine, DSC, SEM, statistical and graphical software such as SPSS, Microsoft Excel and factorial designs
|
|