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Dr Reza Kazemi Oskuee (Pharm. D., Ph.D.)
Assistant Professor of Biotechnology
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Address: School of Medicine, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran
Tel: Fax
oskueekr@ [at]mums.ac.ir ……….[at]yahoo.com Updated at: |
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und Educational Background |
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- Ph.D. in Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran (2008)
- Six month research study in Pharmaceutical Biology-Biotechnology, Department of Pharmacy, Munich Center of Nanoscience (CeNS), Ludwig-Maximilians-University of Munich, Germany (2007)
- Pharm. D., School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran (2003)
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Research Interests |
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Publications |
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1- Martin Meyer, Alexander Philipp, Reza Oskuee, Claudia Schmidt and Ernst Wagner, Breathing life into polycations: functionalization with pH-responsive endosomolytic peptides and polyethylene glycol enables siRNA delivery, J. Am. Chem. Soc.; 2008,130 (11), pp 3272 – 3273 (IF=9.023)
2- R. K. Oskuee, Ali Dehshahri, Wayne. T. Shier, Mohammad Ramezani, Modified Polyethylenimine: Self Assemble Nanoparticle Forming Polymer for pDNA Delivery, Iranian Journal of Basic Medical Sciences, 2008, 11 (1), 33 - 40. (IF=0.343)
3- Malaekeh-Nikouei B., Malaekeh-Nikouei M., Oskuee R. K., Ramezani M., Preparation, characterization and transfection efficiency of nanoliposomes modified with oligoamines as gene carrier, Nanomedicine, 2009 Dec;5(4):457-62. (IF=5.44)
4- Oskuee R. K., Dehshahri A., Shier W.T., Ramezani M., Alkylcarboxylate grafting to polyethylenimine: a simple approach to producing a DNA nanocarrier with low toxicity, J Gene Med., 2009 Oct;11(10):921-32. (IF=3.55)
5- Dehshahri A., Oskuee R. K., Shier W. T., Hatefi A., Ramezani M., Gene transfer efficiency of high primary amine content, hydrophobic, alkyl-oligoamine derivatives of polyethylenimine, Biomaterials, 2009 Sep;30(25):4187-94. (IF=7.882)
6- Reza K. Oskuee, Alexander Philipp, Ali Dehshahri, Ernst Wagner and Mohammad Ramezani, The impact of carboxyalkylation of branched polyethylenimine on effectiveness in small interfering RNA delivery, J. Gene Med. 2010 Sep;12(9):729–738. (IF=3.55)
7- RK Oskuee, MR Jafari, SA Farzad, M Ramezani, In vitro Leishmanicidal activity of Calotropis gigantea and its fractions against Leishmania major, J Med. Plant. Res., 2012 6(23):3977-3983.
8- Dehshahri, A., Oskuee, R.K., Shier, W.T., Ramezani, M. β-Galactosylated alkyl-oligoamine derivatives of polyethylenimine enhanced pDNA delivery into hepatic cells with reduced toxicity, Current Nanoscience, 2012, 8 (4) , pp. 548-555. (IF=1.879)
9- Oskuee, R.K., Dehshahri, A. Ramezani, M., Plasmid DNA delivery into hepatocytes using a multifunctional nanocarrier based on sugar-conjugated polyethylenimine, Gene Ther Mol Biol 2012 Vol 14, 62-71. (IF=0.724).
10- M. Darroudi, M. Sarani, M. Hakimi, R. K. Oskuee, A. Khorsand, L. Gholami, Facile synthesis, characterization, and evaluation of neurotoxicity effect of cerium oxide nanoparticles, Ceram. Int., 2013, 39:6917-6921. (IF=2.086)
11- M. Darroudi, Z. Sabouri, R. K. Oskuee, A. Khorsand Zak, H. Kargar, M. Hasnul Naim Abd Hamid, Sol–gel synthesis, characterization, and neurotoxicity effect of zinc oxide nanoparticles using gum tragacanth, Ceram. Int., 2013, 39: 9195 – 9199. (2.086)
12- R. K. Oskuee, E. Mohtashami, L. Golami, B. Malaekeh-Nikouei, Cationic Liposomes-Polyallylamine-Plasmid Nanocomplexes for Gene Delivery, J Exp Nanosci, 2014. 9 (10): 1026-1034 (IF=1.043)
13- M. Darroudi, M. Sarani, R. K. Oskuee, A. Khorsand, M. S. Amiri, Nanoceria: Gum mediated synthesis and in vitro viability assay, Ceram. Int., 2014, 40: 2863-2868. (IF=2.086)
14- M. Darroudi, M. Sarani, R. K. Oskuee, A. Khorsand Zak, H. A. Hosseini, L. Gholami, Green synthesis and evaluation of metabolic activity of starch mediated nanoceria, Ceram. Int., Jul 2014, 40: 2041-2045. (IF=2.086)
15- M. Darroudi, Z. Sabouri, R. K. Oskuee, A. Khorsand Zak, H. Kargar, M. Hasnul Naim Abd Hamid, Green chemistry approach for the synthesis of ZnO nanopowders and their cytotoxic effects, Ceram. Int., 2014, 40: 4827-4831. (IF=2.086).
16- L. Gholami, H. R. Sadeghnia, M. Darroudi, R. Kazemi Oskuee, Evaluation of genotoxicity and cytotoxicity induced by different molecular weights of polyethylenimine/DNA nanoparticles, Turk J Biol (2014) 38:380-387. (IF=1.216).
17- Reza Kazemi Oskuee, Mahmoud Reza Jaafari, Sara Amani, Mohammad Ramezani, Evaluation of leishmanicidal Effect of Euphorbia erythadenia extract by in vitro leshmanicidal assay using Promastigotes of Leishmania major, Asian Pacific Journal of Tropical Biomedicine, 2014; 4(Suppl 2): S905-S907.
18- A. Dehshahri, H. Sadeghpour, R. Kazemi Oskuee, Z. Sabahi, M. Fadaei, S. Hossaini Alhashemi, E. Mohazabieh, Interleukin-12 plasmid DNA delivery using L-thyroxine-conjugated polyethylenimine nanocarriers, J Nanopart Res, 2014, 16:2423 (IF=2.175).
19- M. Darroudi, S. J. Hosseini, R. K. Oskuee, H. A. Hosseini, L. Gholami, S. Gerayeli, Food-directed synthesis of cerium oxide nanoparticles and their neurotoxicity effects, Ceram. Int., 2014, 40: 7425-7430. (IF=2.086)
20- Majid Darroudi, Mohammad Hakimi, Elham Goodarzi, Reza Kazemi Oskuee, Superparamagnetic iron oxide nanoparticles (SPIONs): Green preparation, characterization and their cytotoxicity effects, Ceram. Int., 2014, 40: 14641–14645. (IF=2.086)
21- Mahmoudi A, Oskuee RK, Ramezani M, Malaekeh-Nikoue B, Preparation and in-vitro transfection efficiency evaluation of modified cationic liposome-polyethyleneimine-plasmid nanocomplexes as a novel gene carrier, Current Drug Delivery, 2014, 11: 1-7 (IF=2.248).
22- R. Kazemi Oskuee, M. R. Jaafari, H. R. Rahimi, M. Lotfi, M. S. Tehranchinia, M. Ramezani, Evaluation of leishmanicidal activity of Euphorbia biossieriana and Euphorbia szovitsii by in vitro leishmanicidal assay using promastigote of Leishmania major, Asian Pacific Journal of Tropical Medicine, Accepted (IF=0.502).
23- M Mirzaei, H Mirzaei, A Sahebkar, A Bagherian, M Masoud Khoi, H Mirzaei, R Salehi, M R Jaafari, R K Oskuee, Phylogenetic Analysis of Selected Menthol-Producing Species Belonging to the Lamiaceae Family, Nucleosides, Nucleotides and Nucleic Acids, 2015, 34:9, 650-657.
24- Oskuee, R.K., Dosti, F., Gholami, L., Malaekeh-Nikouei, B., A simple approach for producing highly efficient DNA carriers with reduced toxicity based on modified polyallylamine, Materials Science and Engineering C, 2015, 49:290-296.
25- S Ayatollahi, M Hashemi, R K Oskuee, Z Salmasi, A Mokhtarzadeh, M Alibolandi, Kh Abnous, M Ramezani, Synthesis of efficient gene delivery systems by grafting pegylated alkylcarboxylate chains to PAMAM dendrimers: Evaluation of transfection efficiency and cytotoxicity in cancerous and mesenchymal stem cells, J Biomater Appl. 2015 30(5) 632–648 (IF=2.197).
26- Askarian S, Abnous K, Taghavi S, Oskuee RK, Ramezani M, Cellular delivery of shRNA using aptamer-conjugated PLL-alkyl-PEInanoparticles, Colloids Surf B Biointerfaces. 2015 Sep 14;136:355-364 (IF=4.152).
27- Saeedeh Askarian, Khalil Abnous, Majid Darroudi, Reza Kazemi Oskuee, Mohammad Ramezani, Gene delivery to neuroblastoma cells by poly (L-lysine)-grafted low molecular weight polyethylenimine copolymers, Biologicals, xxx (2016) 1-7 (IF=1.209)
28- Masoud Homayouni-Tabrizi, Ahmad Asoodeh, Mohammad Mashreghi, Mahere Rezazade Bazaz, Reza Kazemi Oskuee, Majid Darroudi, Attachment of a Frog Skin-Derived Peptide to Functionalized Cerium Oxide Nanoparticles, International Journal of Peptide Research and Therapeutics, 2016 (IF=0.905)
29- R. K. Oskuee, J. Behravan, M. Ramezani,Chemical composition, antimicrobial activity and antiviral activity of essential oil of Carum copticum from Iran, Avicenna Journal of Phytomedicine, 2011, 1(2), 83-90. Rahimi HR, Nedaeinia R, Sepehri Shamloo A, Nikdoust Sh, Kazemi Oskuee R. Novel delivery for natural products: Nano-curcumin formulations. Avicenna J Phytomed, 2016; 6 (4): 383-398.
30- Sadeghi F., Kazemi Oskuee R., Nassirli H., Afrasiabi Garekani H., Effect of granulation process on physicomechanical properties of granules and compaction behaviour of hydroxypropyl methylcellulose with different degrees of methoxy/hydroxypropyl substitution, Pharmaceutical Sciences, 2009, 15(1), 93- 102.
31- M. Darroudi, Z. Sabouri, R. K. Oskuee, H. Kargar, H. A. Hosseini, Neuronal toxicity of biopolymer-template synthesized ZnO nanoparticles, Nanomedicine Journal, 2014, 1, 88-93.
32- H. R. Rahimi, R. Kazemi Oskuee, Curcumin From Traditional Iranian Medicine to Molecular Medicine, Razavi International Journal of Medicine, 2014 May; 2(2): e19982.
33- Reza Kazemi Oskuee, Vahideh Zakeri, Leila Gholami, Bizhan Malaekeh-Nikouei, Preparation, characterization and transfection efficiency of nanoparticles composed of alkane-modified polyallylamine, Nanomedicine Journal, 2014, 2(2): 111-120
34- Rahimi HR, Jaafari MR, Mohammadpour AH, Abnous K, Ghayour-Mobarhan M, Ramezanzadeh E, F Mousavi, R K Oskuee, Curcumin: Reintroduced Therapeutic Agent from Traditional Medicine for Alcoholic Liver Disease. Asia Pac J Med Toxicol, 2015;4: 25-30. 35- Reza Kazemi Oskuee, Azhar Banikamali, Bibi Sedigheh Fazly Bazzaz, Hasan Ali Hosseini and Majid Darroudi, Honey-Based and Ultrasonic-Assisted Synthesis of Silver Nanoparticles and Their Antibacterial Activities, Journal of Nanoscience and Nanotechnology, 2016 16, 7989–7993.
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Presentations |
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- Reza Kazemi Oskuee, Esmat Alinejad-Mofrad, Seyyed Hadi Mousavi, Evaluation of cellular toxicity and genotoxicity effects of poly-L-lysine/pDNA nanoparticles, International Conference on Chemical, Metallurgy and Environmental Engineering, 2015, 3-4 June, Istanbul, Turkey. - Reza K. Oskuee, Tahereh Sajedi, Size-mediated cytotoxicity and apoptosis of polyethylenimine/DNA nanoparticles in murine neuroblastoma Neuro2A cells, NanoFormulation 2012, 28 May-1 June 2012, Barcelona, Spain - Reza K. Oskuee, A. Dehshahri, M. Ramezani and W. T. Shier, Influence of Charge Reduction and Partial Hydrophobization on Gene Delivery Efficiency of High Molecular Weight Polyethylenimine/DNA Nanoparticles, Nanoscience and Nanotechnology 2011,19-23 September 2011, Frascati-Rome, Italy - Reza K. Oskuee, Ali Dehshahri, W. Thomas Shier, Mohammad Ramezani, Glycoconjugated polycation-based nanoparticulate system for the delivery of DNA, NanoThailand 2010, 18-20 November 2010, Bangkok, Thailand. - Reza K. Oskuee, Ali Dehshahri, W. Thomas Shier, Mohammad Ramezani, Synthesis, characterization and transfection efficiency of artificial virus Nanoparticles Based on Modified Polyethylenimines as a Promising non-viral gene Carrier, 2010 Singapore Symposium on Drug Delivery Systems, 20-23 Jun 2010. - Dehshari A, Ramezani M, Kazemi-Oskuee R, Shier WT. Nanocarriers based on hydrophobized PEI-oligoamines for plasmid DNA transfer. 9th International Conference on Nanostructured Materials (Nano 2008). Poster Presentation, 1-6 June, 2008, Rio de Janeiro, Brazil. - M. Ramezani, A. Dehshari, R. Kazemi Oskuee, W.T. Shier., Alkylated Polyethylenimine as efficient vectors for gene delivery. 3rd NanoBio-Europe Congress, Poster presentation, June13-15, 2007, Münster, Germany - R. K. Oskuee, F. Sadeghi, H. Afrasiabi, Investigation of compression properties of different grades of HPMC and Eudragit in direct compression and granulation process, 10th Iranian Pharmaceutical Sciences Conference (IPSC2006), August 21-24, 2006, Tehran, Iran - R. K. Oskuee, A. Dehshahri, Microbial conversion and its application in pharmaceutical sciences, 1st Conference of Biology & Society, March 2004, Mashhad, Iran - A. Dehshahri, R K. Oskuee, Ethical Aspects of Human Cloning, 1st Conference of Biology & Society, March 2004, Mashhad, Iran - R. K. Oskuee, F. Sadeghi, Preparation and evaluation of sustained release matrix tablets of sodium diclofenac based on aqueous dispersions of Eudragit RS and RL, 7th Iranian Seminar of Pharmacy Students, Nov. 2001, Isfahan, Iran - Oskuee, R. K., Gholami, L., Sadeghnia, H. R., Balali-Mood M, Evaluation of genotoxicity induced by Polyetylenimin 25KDa nanoparticles with an alkaline single cell gel electrophoresis (comet) assay, Oral presentatation, 5th Iranian Controlled Release Conference (ICRC 2011), 4th-6th October 2011, Mashhad, Iran - Reza K. Oskuee, Ali Dehshahri, W. Thomas Shier, Mohammad Ramezani, Targeted Plasmid DNA Delivery by Galactosylated Alkyl-Oligoamine Derivatives of PEI, Oral presentatation, The 4th Iranian Controlled Release Conference, 6-8 Oct 2009, Zanjan, Iran
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Honors & Awards |
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Members hip Membership |
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Administrative Responsibilities |
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Other Skills |
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